A Unique Spectrum of Somatic PIK3CA (p110α) Mutations Within Primary Endometrial Carcinomas
نویسندگان
چکیده
منابع مشابه
A unique spectrum of somatic PIK3CA (p110alpha) mutations within primary endometrial carcinomas.
PURPOSE The goal of this study was to comprehensively define the incidence of mutations in all exons of PIK3CA in both endometrioid endometrial cancer (EEC) and nonendometrioid endometrial cancer (NEEC). EXPERIMENTAL DESIGN We resequenced all coding exons of PIK3CA and PTEN, and exons 1 and 2 of KRAS, from 108 primary endometrial tumors. Somatic mutations were confirmed by sequencing matched ...
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The phosphoinositide-3-kinase (PI3K) signaling pathway has been implicated in the development of endometrioid endometrial adenocarcinoma (EEC). Recently, The Cancer Genome Atlas (TCGA) project stratified EEC into four molecular subgroups, with the majority of tumors falling into the copy-number low-EEC (CNL-EEC) molecular subgroup. The aim of the present study was to investigate whether alterat...
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The PIK3 signaling pathway has been identified as one of the most important and most frequently mutated pathways in breast cancer. Somatic mutations in the catalytic subunit of PIK3CA have been found in a significant fraction of breast carcinomas, and it has been proposed that mutant PIK3CA plays a role in tumor initiation. However, the majority of primary human tumors analyzed for genetic alte...
متن کاملFacial Infiltrating Lipomatosis Contains Somatic PIK3CA Mutations in Multiple Tissues.
INTRODUCTION: Facial infiltrating lipomatosis (FIL) is a rare congenital disorder that causes overgrowth of one side of the face, that can include premature dental eruption, hemimacroglossia, macrodontia, and mucosal neuromas. 1 We recently reported that affected subcutaneous adipose tissue in patients with FIL contains mutant cells with somatic gain-of-function mutations in PIK3CA. 2 The purpo...
متن کاملSynchronous dual primary ovarian and endometrial carcinomas.
OBJECTIVES The synchronous occurrence of carcinoma confined to the ovary and endometrium presents a diagnostic and therapeutic dilemma. These tumors have been variously staged as FIGO Stage IIA ovarian carcinoma, Stage III endometrial carcinoma, or synchronous dual primary carcinomas. Accumulating evidence suggests such patients have a favorable outcome. This retrospective study was undertaken ...
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2011
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-10-0540